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CRRD ID: 3447
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Acc ID: DOID:769
Term: neuroblastoma
Definition: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Definition Source(s): MESH:D009447,
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISOCRRD:7317468554872ClinVarClinVar Annotator: match by term: Neuroblastoma

PMID:12717436, PMID:14644997, PMID:14982869, PMID:15385933, PMID:15667533, PMID:15710330, PMID:15834506, PMID:15928039, PMID:15951301, PMID:16358218, PMID:17330262, PMID:17972951, PMID:19047918, PMID:19179468, PMID:24033266, PMID:25097206, PMID:25395418, PMID:26619011, PMID:28098151
 ISOCRRD:7317468554872ClinVarClinVar Annotator: match by term: Neuroblastoma

PMID:12717436, PMID:14644997, PMID:14982869, PMID:15385933, PMID:15928039, PMID:16358218, PMID:16518851, PMID:17177198, PMID:19047918, PMID:23756559, PMID:24033266, PMID:25097206, PMID:26619011
 ISOCRRD:7317468554872ClinVarClinVar Annotator: match by term: Neuroblastoma

 ISOCRRD:7317468554872ClinVarClinVar Annotator: match by term: NEUROBLASTOMA, SUSCEPTIBILITY TO

PMID:12717436, PMID:26619011
 ISOCRRD:73174611554173CTDCTD Direct Evidence: marker/mechanism

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.