GENE - TERM ANNOTATION REPORT

CRRD ID: 3629
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Scn10a
Name: sodium voltage-gated channel alpha subunit 10
Acc ID: DOID:0060224
Term: atrial fibrillation
Definition: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Definition Source(s): MESH:D001281, http://en.wikipedia.org/wiki/Atrial_fibrillation, http://www.mayoclinic.org/diseases-conditions/atrial-fibrillation/basics/definition/con-20027014, http://www.nhlbi.nih.gov/health/health-topics/topics/af
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISOCRRD:134908611554173CTDCTD Direct Evidence: marker/mechanism

PMID:20062060, PMID:29892015, PMID:30061737
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.