GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3704
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Slc2a1
Name: solute carrier family 2 member 1
Acc ID: CHEBI:131461
Term: 3-bromopyruvic acid
Definition: A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug
Chemical ID: MESH:C017092
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:113056480464CTDbromopyruvate results in decreased expression of SLC2A1 mRNA

bromopyruvate results in decreased expression of SLC2A1 protein

PMID:28433571
multiple interactionsISOCRRD:113056480464CTD[bromopyruvate results in decreased expression of SLC2A1 protein] which results in decreased uptake of Glucose

PMID:28433571
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.