GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3771
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:7321856480464CTDdeoxynivalenol results in increased expression of STAT1 mRNA

PMID:22454431
increases phosphorylationISOCRRD:7321856480464CTDdeoxynivalenol results in increased phosphorylation of STAT1 protein

PMID:22454431
multiple interactionsISOCRRD:7321856480464CTD[deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of STAT1 mRNA

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]

stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]

stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]

PMID:22454431, PMID:28935500
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.