Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3771
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases phosphorylationEXP 6480464CTDHydrogen Peroxide results in increased phosphorylation of STAT1 protein

PMID:17607690
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of STAT1 protein]

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of STAT1 protein]

PMID:17607690
affects localizationISOCRRD:7321846480464CTDHydrogen Peroxide affects the localization of STAT1 protein

PMID:10364193
multiple interactionsISOCRRD:7321846480464CTDHydrogen Peroxide affects the reaction [vanadium pentoxide results in increased phosphorylation of and results in increased activity of STAT1 protein]

Hydrogen Peroxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]

Hydrogen Peroxide inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]

Hydrogen Peroxide inhibits the reaction [IFNG protein affects the localization of STAT1 protein]

Hydrogen Peroxide inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]

PMID:15748169, PMID:18322232, PMID:19635391
multiple interactionsISOCRRD:7321856480464CTDHydrogen Peroxide inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]

Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]

PMID:12847270
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.