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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3771
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:5847
Term: ICI D1694
Definition: A N-acyl-amino acid that has formula C21H22N4O6S.
Chemical ID: MESH:C068874
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases phosphorylationISOCRRD:7321846480464CTDraltitrexed results in increased phosphorylation of STAT1 protein

PMID:16204068
multiple interactionsISOCRRD:7321846480464CTDSTAT1 protein promotes the reaction [raltitrexed results in increased localization of FAS protein]

TP53 protein inhibits the reaction [raltitrexed results in increased phosphorylation of STAT1 protein]

PMID:16204068
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