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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3845
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tf
Name: transferrin
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCopper results in decreased expression of TF mRNA

PMID:30556269
increases expressionEXP 6480464CTDCopper deficiency results in increased expression of TF protein

PMID:18993053
multiple interactionsEXP 6480464CTDCopper deficiency results in decreased expression of [Iron binds to TF protein]

PMID:20164366
affects bindingISORGD:13425936480464CTDCopper binds to TF protein modified form, TF protein binds to Copper

PMID:14534351, PMID:15359738, PMID:21792595, PMID:23896426
multiple interactionsISORGD:13425936480464CTD[triazacyclononane analog co-treated with Copper] binds to TF protein, Polysaccharides affects the reaction [Copper binds to TF protein modified form]

PMID:21429825, PMID:21792595
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.