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CRRD ID: 3845
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tf
Name: transferrin
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCopper results in decreased expression of TF mRNA

increases expressionEXP 6480464CTDCopper deficiency results in increased expression of TF protein

multiple interactionsEXP 6480464CTDCopper deficiency results in decreased expression of [Iron binds to TF protein]

affects bindingISORGD:13425936480464CTDCopper binds to TF protein modified form, TF protein binds to Copper

PMID:14534351, PMID:15359738, PMID:21792595, PMID:23896426
multiple interactionsISORGD:13425936480464CTD[triazacyclononane analog co-treated with Copper] binds to TF protein, Polysaccharides affects the reaction [Copper binds to TF protein modified form]

PMID:21429825, PMID:21792595
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.