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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3845
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tf
Name: transferrin
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases oxidationEXP 6480464CTDDoxorubicin results in increased oxidation of TF protein

PMID:28818578
increases secretionEXP 6480464CTDDoxorubicin results in increased secretion of TF protein

PMID:28885000
multiple interactionsISORGD:13425936480464CTD[Doxorubicin binds to TF protein] which results in increased activity of CASP3 protein, [Doxorubicin binds to TF protein] which results in increased activity of CASP8 protein, [Doxorubicin binds to TF protein] which results in increased activity of CASP9 protein, [Doxorubicin binds to TF protein] which results in increased activity of PARP1 protein

PMID:24998637
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.