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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3910
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tshb
Name: thyroid stimulating hormone subunit beta
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases secretionEXP 6480464CTDEstradiol results in increased secretion of TSHB protein

PMID:29305326
multiple interactionsEXP 6480464CTD[Estradiol co-treated with 4, 4'-hexafluorisopropylidene diphenol] results in increased expression of TSHB mRNA, [Estradiol co-treated with bisphenol A] results in increased expression of TSHB mRNA, Estradiol inhibits the reaction [TRH protein results in increased secretion of TSHB protein], Estradiol promotes the reaction [TRH protein results in increased secretion of TSHB protein]

PMID:16570238, PMID:29305326, PMID:30099086
multiple interactionsISORGD:7326056480464CTDEstradiol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]

PMID:19766106
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.