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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3910
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tshb
Name: thyroid stimulating hormone subunit beta
Acc ID: CHEBI:63613
Term: nevirapine
Definition: A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.
Chemical ID: MESH:D019829
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7326056480464CTD[Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA, [Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 protein, Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine], sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]

PMID:16030158
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.