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GENE - TERM ANNOTATION REPORT

CRRD ID: 3910
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tshb
Name: thyroid stimulating hormone subunit beta
Acc ID: DOID:1459
Term: hypothyroidism
Definition: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.
Definition Source(s): MESH:D007037, http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001393/
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:732605737692CRRDDNA:nonsense mutation:exon:94G>T (p.E11X) (human)

 
 ISORGD:7326058554872ClinVarClinVar Annotator: match by term: THYROID-STIMULATING HORMONE DEFICIENCY

PMID:11297590, PMID:11549695
 ISORGD:7326058554872ClinVarClinVar Annotator: match by term: THYROID-STIMULATING HORMONE DEFICIENCY

PMID:11788671, PMID:15292359
 ISORGD:7326058554872ClinVarClinVar Annotator: match by term: THYROID-STIMULATING HORMONE DEFICIENCY

PMID:12364478, PMID:8636437, PMID:9589689
 ISORGD:7326058554872ClinVarClinVar Annotator: match by term: THYROID-STIMULATING HORMONE DEFICIENCY

PMID:1971148
 ISORGD:7326058554872ClinVarClinVar Annotator: match by term: THYROID-STIMULATING HORMONE DEFICIENCY

PMID:25741868
 ISORGD:7326058554872ClinVarClinVar Annotator: match by term: THYROID-STIMULATING HORMONE DEFICIENCY

PMID:2792087
 ISORGD:73260511554173CTDCTD Direct Evidence: marker/mechanism

PMID:18031379, PMID:24729111
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