GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3952
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDAtorvastatin inhibits the reaction [sodium arsenite results in increased expression of VCAM1 protein]

Atorvastatin inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]

Atorvastatin inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]

PMID:17589825, PMID:25058445
decreases expressionISOCRRD:7309886480464CTDAtorvastatin results in decreased expression of VCAM1 mRNA

Atorvastatin results in decreased expression of VCAM1 protein

PMID:17673219, PMID:22245985
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.