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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3952
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDStreptozocin results in increased expression of VCAM1 mRNA

Streptozocin results in increased expression of VCAM1 protein

PMID:16129698, PMID:16139267, PMID:16979161, PMID:17589825, PMID:25199697
multiple interactionsEXP 6480464CTD[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA

Atorvastatin inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]

Atorvastatin inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]

Bezafibrate inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]

candesartan inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]

KLK1 protein inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]

Pioglitazone inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]

procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]

PMID:16129698, PMID:16139267, PMID:16979161, PMID:17589825, PMID:25199697, PMID:28946194
increases expressionISOCRRD:114816480464CTDStreptozocin results in increased expression of VCAM1 mRNA

PMID:28700904
multiple interactionsISOCRRD:114816480464CTD[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 protein

Curcumin analog inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]

sulforafan inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 protein]

PMID:24707343, PMID:28700904
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.