GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61308
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Flt3
Name: fms-related tyrosine kinase 3
Acc ID: CHEBI:78543
Term: ponatinib
Definition: A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline.
Chemical ID: MESH:C545373
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISOCRRD:13217146480464CTDponatinib analog results in decreased activity of FLT3 protein

ponatinib results in decreased activity of FLT3 protein

ponatinib results in decreased activity of FLT3 protein mutant form

PMID:19878872, PMID:21561767, PMID:22409268
decreases phosphorylationISOCRRD:13217146480464CTDponatinib results in decreased phosphorylation of FLT3 protein mutant form

PMID:21482694
multiple interactionsISOCRRD:13217146480464CTDponatinib inhibits the reaction [FLT3 protein mutant form results in increased phosphorylation of FLT3 protein mutant form]

PMID:22409268
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.