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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7339066480464CTDGlucose results in increased expression of TIMP2 protein

PMID:21367880
multiple interactionsISORGD:7339066480464CTD[Glucose co-treated with Air Pollutants] results in decreased expression of TIMP2 mRNA, [Glucose co-treated with Particulate Matter] results in decreased expression of TIMP2 mRNA, isoangustone A inhibits the reaction [Glucose results in increased expression of TIMP2 protein]

PMID:21367880, PMID:26179980
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.