Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:621786480464CTDTetrachlorodibenzodioxin affects the expression of TIMP2 mRNA

PMID:21570461
decreases expressionISORGD:7339066480464CTDTetrachlorodibenzodioxin results in decreased expression of TIMP2 mRNA

PMID:19684285
increases expressionISORGD:621786480464CTDTetrachlorodibenzodioxin results in increased expression of TIMP2 mRNA

PMID:15667827, PMID:17586704
increases expressionISORGD:7339066480464CTDTetrachlorodibenzodioxin results in increased expression of TIMP2 mRNA

PMID:19684285, PMID:20106945, PMID:21632981
multiple interactionsISORGD:621786480464CTDTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA]

PMID:16054899
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.