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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7339066480464CTDfulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA], fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein], fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA], fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein], fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA], fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]

PMID:19956873
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.