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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619573
Species: Mus musculus
CRRD Object: Gene
Symbol: Slc22a6
Name: solute carrier family 22 (organic anion transporter), member 6
Acc ID: CHEBI:17775
Term: 7,9-dihydro-1H-purine-2,6,8(3H)-trione
Definition: An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Chemical ID: MESH:D014527
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a6affects secretionEXP 6480464CTDSLC22A6 protein affects the secretion of Uric Acid

PMID:19605544
Slc22a6increases uptakeISORGD:6195726480464CTDSLC22A6 protein results in increased uptake of Uric Acid

PMID:12472777
Slc22a6multiple interactionsISORGD:6195726480464CTD4, 4'-Diisothiocyanostilbene-2, 2'-Disulfonic Acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid], Benzbromarone inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid], gluconic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid], Glutarates promotes the reaction [SLC22A6 protein results in increased uptake of Uric Acid], Ketoglutaric Acids inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid], p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Uric Acid], Probenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid], pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid], Salicylates inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]

PMID:12472777
Slc22a6multiple interactionsISORGD:693386480464CTD[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A6 protein

PMID:19605544
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.