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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619573
Species: Mus musculus
CRRD Object: Gene
Symbol: Slc22a6
Name: solute carrier family 22 (organic anion transporter), member 6
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a6decreases expressionISORGD:693386480464CTDMethotrexate results in decreased expression of SLC22A6 protein

PMID:16925582
Slc22a6increases response to substanceISORGD:6195726480464CTDSLC22A6 protein results in increased susceptibility to Methotrexate

PMID:27377006
Slc22a6increases uptakeISORGD:6195726480464CTDSLC22A6 protein results in increased uptake of Methotrexate

PMID:16098483, PMID:27377006, PMID:28890383
Slc22a6multiple interactionsISORGD:6195726480464CTDresveratrol inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate], rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]

PMID:27377006, PMID:28890383
Slc22a6multiple interactionsISORGD:693386480464CTDLeucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A6 protein]

PMID:16925582
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.