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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61967
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mcm6
Name: minichromosome maintenance complex component 6
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13528546480464CTDEstradiol results in increased expression of MCM6 mRNA

PMID:16474171, PMID:17622325, PMID:19167446
multiple interactionsISORGD:13528546480464CTD[Estradiol co-treated with Parathion] results in increased expression of MCM6 mRNA

PMID:17622325
multiple interactionsISORGD:622606480464CTDEstradiol inhibits the reaction [Progesterone affects the localization of MCM6 protein]

PMID:16966611
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.