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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619755
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Rac1
Name: Rac family small GTPase 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDLipopolysaccharides results in increased activity of RAC1 protein

PMID:17448908
multiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA]

PMID:16401727
increases activityISOCRRD:15535316480464CTDLipopolysaccharides results in increased activity of RAC1 protein

PMID:21511011
increases activityISOCRRD:16054326480464CTDLipopolysaccharides results in increased activity of RAC1 protein

PMID:18625914, PMID:21417583
increases localizationISOCRRD:16054326480464CTDLipopolysaccharides results in increased localization of RAC1 protein

PMID:18625914
increases prenylationISOCRRD:16054326480464CTDLipopolysaccharides results in increased prenylation of RAC1 protein

PMID:18625914
multiple interactionsISOCRRD:15535316480464CTDNSC 23766 inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]

PMID:21511011
multiple interactionsISOCRRD:16054326480464CTDAzithromycin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]]

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]]

Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]

Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]

Simvastatin inhibits the reaction [Lipopolysaccharides results in increased prenylation of RAC1 protein]

PMID:18625914, PMID:21417583
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.