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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619790
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Rag1
Name: recombination activating 1
Acc ID: CHEBI:35455
Term: 1-naphthyl isothiocyanate
Definition: An isothiocyanate that has formula C11H7NS.
Chemical ID: MESH:D015058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:13178776480464CTDRAG1 gene mutant form results in decreased susceptibility to 1-Naphthylisothiocyanate

PMID:28049044
multiple interactionsISORGD:13178776480464CTDRAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ALPL protein], RAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA], RAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA], RAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]

PMID:28049044
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.