GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619799
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Vegfb
Name: vascular endothelial growth factor B
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISOCRRD:16223546480464CTDTetrachlorodibenzodioxin affects the expression of VEGFB mRNA

PMID:21570461, PMID:26377647
increases expressionISOCRRD:16223546480464CTDTetrachlorodibenzodioxin results in increased expression of VEGFB mRNA

PMID:12167310, PMID:19182260
multiple interactionsISOCRRD:16223546480464CTD[AHR gene mutant form results in decreased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of VEGFB mRNA

[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of VEGFB mRNA

PMID:16214954, PMID:24035824
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.