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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620029
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7327516480464CTDTretinoin results in decreased expression of NR4A1 mRNA

PMID:23830798
multiple interactionsISORGD:7327516480464CTDleptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]], Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein], Tretinoin inhibits the reaction [Indomethacin results in increased expression of NR4A1 mRNA], Tretinoin results in increased activity of [NR4A1 protein binds to RXRA protein]

PMID:10919358, PMID:14592536
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.