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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620029
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7327526480464CTDTetrachlorodibenzodioxin affects the expression of NR4A1 mRNA

PMID:16962184, PMID:24058054, PMID:28922406
decreases expressionISORGD:7327526480464CTDTetrachlorodibenzodioxin results in decreased expression of NR4A1 mRNA

PMID:26290441
increases expressionISORGD:7327516480464CTDTetrachlorodibenzodioxin results in increased expression of NR4A1 mRNA

PMID:26238291
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.