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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620029
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Acc ID: CHEBI:47697
Term: 4,5,6,7-TETRABROMOBENZOTRIAZOLE
Definition: A benzotriazole that has formula C6HBr4N3.
Chemical ID: MESH:C405354
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7327526480464CTD4, 5, 6, 7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to NR4A1 promoter]], 4, 5, 6, 7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of NR4A1 mRNA]

PMID:26301327
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.