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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620267
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: S100a9
Name: S100 calcium binding protein A9
Acc ID: CHEBI:28714
Term: S-butyl-DL-homocysteine (S,R)-sulfoximine
Definition: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
Chemical ID: MESH:D019328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]

PMID:26177832
multiple interactionsISOCRRD:7331756480464CTD[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA

[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA

[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of S100A9 mRNA

PMID:23986454, PMID:28263783, PMID:29154782
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.