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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620403
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ccs
Name: copper chaperone for superoxide dismutase
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Copper Sulfate co-treated with 2, 3, 2-tetramine] results in increased degradation of CCS protein, benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Copper Sulfate co-treated with 2, 3, 2-tetramine] results in increased degradation of CCS protein], Copper Sulfate inhibits the reaction [2, 3, 2-tetramine results in increased expression of CCS protein], lactacystin inhibits the reaction [[Copper Sulfate co-treated with 2, 3, 2-tetramine] results in increased degradation of CCS protein]

PMID:12832419
decreases expressionISORGD:7336066480464CTDCopper Sulfate results in decreased expression of CCS mRNA

PMID:19549813
multiple interactionsISORGD:7336066480464CTD[Copper Sulfate co-treated with CP protein] results in increased expression of CCS mRNA, Copper Sulfate inhibits the reaction [2, 3, 2-tetramine results in increased expression of CCS protein]

PMID:12832419, PMID:17683925
multiple interactionsISORGD:7336076480464CTDCopper Sulfate inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]

PMID:19039664
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.