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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620403
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ccs
Name: copper chaperone for superoxide dismutase
Acc ID: CHEBI:52722
Term: lactacystin
Definition: L-Cysteine substituted at nitrogen by an acetyl group and at sulfur by a substituted-lactam carbonyl group.
Chemical ID: MESH:C067713
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDlactacystin inhibits the reaction [[Copper Sulfate co-treated with 2, 3, 2-tetramine] results in increased degradation of CCS protein]

PMID:12832419
multiple interactionsISORGD:7336076480464CTDlactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein], lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]

PMID:19039664
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.