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GENE - TERM ANNOTATION REPORT

CRRD ID: 620594
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ccr4
Name: C-C motif chemokine receptor 4
Acc ID: GO:0019956
Term: chemokine binding
Definition: Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
Definition Source(s): GOC:ai, GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, PMID:12183377
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAPANTHER:PTN001200797, UniProtKB:P49682, ZFIN:ZDB-GENE-031116-6113792537GO_CentralPMID:21873635

 
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