GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620600
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:7315426480464CTDAcetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NOX4 mRNA]

Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NOX4 protein]

Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]

Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NOX4 mRNA]

Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NOX4 protein]

PMID:21131394, PMID:24224404
multiple interactionsISOCRRD:7315436480464CTDAcetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA]

Acetylcysteine inhibits the reaction [salubrinal results in increased expression of [Cisplatin results in increased expression of NOX4 protein]]

PMID:21616140, PMID:30037311
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.