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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620600
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:3347
Term: candesartan
Definition: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.
Chemical ID: MESH:C081643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDcandesartan results in decreased expression of NOX4

PMID:21107329
multiple interactionsEXP 6480464CTDAmlodipine promotes the reaction [candesartan results in decreased expression of NOX4]

Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4]

PMID:21107329
decreases expressionISOCRRD:7315426480464CTDcandesartan results in decreased expression of NOX4 protein

PMID:18551021
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.