GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620600
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7315426480464CTDcobaltous chloride results in decreased expression of NOX4 mRNA

PMID:19320972
decreases expressionISOCRRD:7315436480464CTDcobaltous chloride results in decreased expression of NOX4 mRNA

cobaltous chloride results in decreased expression of NOX4 protein

PMID:24412703
increases expressionISOCRRD:7315436480464CTDcobaltous chloride results in increased expression of NOX4 mRNA

cobaltous chloride results in increased expression of NOX4 protein

PMID:16507596
multiple interactionsISOCRRD:7315436480464CTDPOMC protein modified form inhibits the reaction [cobaltous chloride results in decreased expression of NOX4 mRNA]

POMC protein modified form inhibits the reaction [cobaltous chloride results in decreased expression of NOX4 protein]

PMID:24412703
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.