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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620600
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:5356
Term: ginkgolide B
Definition: A ginkgolide in which the pro-R hydrogens at positions 6, 12, and 17 of the 8-tert-butyl-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0(1,11).0(3,7).0(7,11).0(13,17)]nonadecane-5,15,18-trione ginkgolide skeleton have been replaced by hydroxy groups.
Chemical ID: MESH:C045856
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7315436480464CTDginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]], ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA], ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 protein], MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]], TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]], TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]

PMID:26768586
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.