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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620621
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Bcl2a1
Name: BCL2-related protein A1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7339856480464CTDTretinoin results in increased expression of BCL2A1 mRNA, Tretinoin results in increased expression of BCL2A1A protein

PMID:10673743, PMID:11133770, PMID:12130515, PMID:15498508, PMID:15894607, PMID:16572199
multiple interactionsISORGD:7339856480464CTD[Tretinoin co-treated with arsenic trioxide co-treated with Butyrates] results in increased expression of BCL2A1 mRNA, [Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA, [Tretinoin co-treated with arsenic trioxide] results in increased expression of BCL2A1 mRNA, [Tretinoin co-treated with Butyrates] results in increased expression of BCL2A1 mRNA, [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA, [Tretinoin results in increased expression of BCL2A1 mRNA] which results in decreased susceptibility to Doxorubicin, arsenic trioxide inhibits the reaction [Tretinoin results in increased expression of BCL2A1A protein]

PMID:11133770, PMID:12130515, PMID:15894607, PMID:16572199
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.