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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620634
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hr
Name: HR, lysine demethylase and nuclear receptor corepressor
Acc ID: CHEBI:15738
Term: staurosporine
Definition: An indolocarbazole alkaloid that has formula C28H26N4O3.
Chemical ID: MESH:D019311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDHR protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]

HR protein inhibits the reaction [Staurosporine results in increased expression of TP53 protein]

PMID:20886113
affects response to substanceISOCRRD:7357966480464CTDHR protein affects the susceptibility to Staurosporine

PMID:20886113
multiple interactionsISOCRRD:7357966480464CTDHR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]

TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]

PMID:20886113
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.