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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620707
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tff1
Name: trefoil factor 1
Acc ID: CHEBI:67040
Term: S-adenosyl-L-methioninate
Definition: A sulfonium betaine that is a conjugate base of S-adenosyl-L-methionine obtained by the deprotonation of the carboxy group.
Chemical ID: MESH:D012436
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13446716480464CTDS-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA], S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA]

PMID:22558281
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.