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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620732
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ephx2
Name: epoxide hydrolase 2
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7310556480464CTDEPHX2 gene mutant form affects the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone], EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]

PMID:19896470
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.