GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 62081
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hes1
Name: hes family bHLH transcription factor 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDValproic Acid results in increased expression of HES1 mRNA

PMID:29968957
multiple interactionsEXP 6480464CTDcaffeic acid inhibits the reaction [Valproic Acid results in increased expression of HES1 mRNA]

PMID:29968957
decreases expressionISOCRRD:16054346480464CTDValproic Acid results in decreased expression of HES1 mRNA

PMID:23179753, PMID:28001369, PMID:29154799
increases expressionISOCRRD:16054346480464CTDValproic Acid results in increased expression of HES1 mRNA

PMID:23179753, PMID:26272509, PMID:27188386
increases methylationISOCRRD:16054346480464CTDValproic Acid results in increased methylation of HES1 gene

PMID:29154799
multiple interactionsISOCRRD:16054346480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HES1 mRNA

PMID:27188386
multiple interactionsISOCRRD:623736480464CTDKDM1A protein affects the reaction [Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of HES1 mRNA]]

Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of HES1 mRNA]

PMID:27645313
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.