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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:16359
Term: cholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Chemical ID: MESH:D019826
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCholic Acid results in increased expression of NR0B2 mRNA

PMID:14684380
multiple interactionsEXP 6480464CTD[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of NR0B2 mRNA

PMID:14684380
increases expressionISORGD:7328736480464CTDCholic Acid results in increased expression of NR0B2 mRNA

PMID:25055961
increases expressionISORGD:7328746480464CTDCholic Acid results in increased expression of NR0B2 mRNA, Cholic Acid results in increased expression of SHP mRNA

PMID:12072388, PMID:15694933, PMID:16002565, PMID:16269825, PMID:17521389, PMID:24189133, PMID:25582706
multiple interactionsISORGD:7328746480464CTD[Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA, IL1B protein inhibits the reaction [Cholic Acid results in increased expression of NR0B2 mRNA]

PMID:12072388, PMID:22540009
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.