Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDChenodeoxycholic Acid results in increased expression of NR0B2 mRNA

PMID:15980055, PMID:16357303, PMID:27743861, PMID:29222744
multiple interactionsEXP 6480464CTD[Chenodeoxycholic Acid binds to NR1H4 protein] which results in increased expression of NR0B2 mRNA

PMID:19562681
increases expressionISORGD:7328736480464CTDChenodeoxycholic Acid results in increased expression of NR0B2 mRNA

PMID:16037943, PMID:16269825, PMID:16946559, PMID:19072826, PMID:19562681, PMID:22178739, PMID:22291955, PMID:22540009, PMID:25055961, PMID:27174168
increases expressionISORGD:7328746480464CTDChenodeoxycholic Acid results in increased expression of NR0B2 mRNA

PMID:16946559, PMID:24189133, PMID:25582706
multiple interactionsISORGD:7328736480464CTD7-hydroxytheonellasterol inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA], [Chenodeoxycholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA, epigallocatechin gallate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA], NR1H4 affects the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]

PMID:17963371, PMID:19072826, PMID:22178739, PMID:22291955
multiple interactionsISORGD:7328746480464CTDNR1H4 protein promotes the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]

PMID:16946559
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.