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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of NR0B2 mRNA

PMID:16054898, PMID:20959002, PMID:21215274
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of NR0B2 mRNA

PMID:20558275
affects expressionISORGD:7328746480464CTDTetrachlorodibenzodioxin affects the expression of NR0B2 mRNA

PMID:24058054
decreases expressionISORGD:7328736480464CTDTetrachlorodibenzodioxin results in decreased expression of NR0B2 mRNA

PMID:20106945, PMID:21632981
increases expressionISORGD:7328746480464CTDTetrachlorodibenzodioxin results in increased expression of NR0B2 mRNA

PMID:29452137
multiple interactionsISORGD:7328736480464CTDNR0B2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA], NR0B2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]

PMID:11368516
multiple interactionsISORGD:7328746480464CTD[AHR gene mutant form affects the susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of NR0B2 mRNA, [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR0B2 mRNA, AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NR0B2 mRNA]

PMID:17942748, PMID:29452137
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.