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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7328746480464CTDpirinixic acid results in increased expression of NR0B2 mRNA

PMID:17426115, PMID:18445702, PMID:19176532
multiple interactionsISORGD:7328736480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NR0B2 mRNA

PMID:19710929
multiple interactionsISORGD:7328746480464CTDNR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with pirinixic acid] results in increased expression of CYP4A14 mRNA], RXRA protein inhibits the reaction [pirinixic acid results in increased expression of NR0B2 mRNA]

PMID:19176532, PMID:19593819
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.