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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:35455
Term: 1-naphthyl isothiocyanate
Definition: An isothiocyanate that has formula C11H7NS.
Chemical ID: MESH:D015058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTD1-Naphthylisothiocyanate results in decreased expression of NR0B2 mRNA

PMID:30723492
increases expressionEXP 6480464CTD1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA

PMID:27317372
multiple interactionsEXP 6480464CTDdioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]

PMID:27317372
increases expressionISORGD:7328736480464CTD1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA

PMID:17175557
increases expressionISORGD:7328746480464CTD1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA

PMID:19181614, PMID:25655198
multiple interactionsISORGD:7328736480464CTD[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of NR0B2 mRNA

PMID:27344345
multiple interactionsISORGD:7328746480464CTD[NR1H4 protein results in increased susceptibility to 1-Naphthylisothiocyanate] which results in increased expression of NR0B2 mRNA, [PPARA protein affects the susceptibility to 1-Naphthylisothiocyanate] which affects the expression of NR0B2 mRNA, alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA], NFE2L2 promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA], pregna-4, 17-diene-3, 16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]]

PMID:19181614, PMID:25655198, PMID:29968724, PMID:30352267
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.