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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of NR0B2 mRNA

PMID:23146761
increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of NR0B2 mRNA

PMID:16487557, PMID:17108234
increases expressionISORGD:7328746480464CTDEthinyl Estradiol results in increased expression of NR0B2 mRNA

PMID:29112739
multiple interactionsISORGD:7328746480464CTD[Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of NR0B2 mRNA], [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR0B2 mRNA, ESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of NR0B2 mRNA]

PMID:12072388, PMID:17942748, PMID:29112739
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.