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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tnc
Name: tenascin C
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:16151566480464CTDTetrachlorodibenzodioxin affects the expression of TNC mRNA

PMID:16611356, PMID:21570461, PMID:26377647
decreases expressionISORGD:13541446480464CTDTetrachlorodibenzodioxin results in decreased expression of TNC mRNA

PMID:29704546
decreases expressionISORGD:16151566480464CTDTetrachlorodibenzodioxin results in decreased expression of TNC mRNA

PMID:15034205, PMID:17586704
increases expressionISORGD:16151566480464CTDTetrachlorodibenzodioxin results in increased expression of TNC mRNA

PMID:15251184, PMID:26139165, PMID:27562557
multiple interactionsISORGD:13541446480464CTD[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of TNC mRNA

PMID:29704546
multiple interactionsISORGD:16151566480464CTD[Tetrachlorodibenzodioxin co-treated with Decitabine] results in increased expression of TNC mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TNC mRNA, AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TNC mRNA]

PMID:15034205, PMID:15251184, PMID:25975270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.