GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621063
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Csf1
Name: colony stimulating factor 1
Acc ID: CHEBI:28088
Term: genistein
Definition: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:7310676480464CTD[CSF1 protein co-treated with TNFSF11 protein co-treated with Genistein] results in decreased expression of CTSK mRNA

[Zinc Sulfate co-treated with Genistein co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of ACP5 mRNA

Cycloheximide inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]]

Dichlororibofuranosylbenzimidazole inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]]

Genistein promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of CTSK mRNA]

Genistein promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of NFATC1 mRNA]

Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]

Zinc Sulfate promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Genistein] results in decreased expression of CTSK mRNA]

PMID:17295206
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.