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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621087
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Socs3
Name: suppressor of cytokine signaling 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of SOCS3 mRNA

PMID:22298810
affects expressionISOCRRD:7308346480464CTDTetrachlorodibenzodioxin affects the expression of SOCS3 mRNA

PMID:21570461
increases expressionISOCRRD:7308336480464CTDTetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA

PMID:21496263
increases expressionISOCRRD:7308346480464CTDTetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA

PMID:17407152, PMID:18684927, PMID:18691609, PMID:19063610, PMID:19770486, PMID:20819909, PMID:21496263, PMID:25975270
multiple interactionsISOCRRD:7308336480464CTD[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased expression of SOCS3 mRNA

PMID:19578757
multiple interactionsISOCRRD:7308346480464CTD[Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of SOCS3 mRNA

[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SOCS3 mRNA

Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]

arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]

Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]

Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SOCS3 gene]

PMID:17407152, PMID:19063610, PMID:20819909, PMID:25975270, PMID:28774668
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.