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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621087
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Socs3
Name: suppressor of cytokine signaling 3
Acc ID: CHEBI:42491
Term: flavone
Definition: The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.
Chemical ID: MESH:C043562
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:7308336480464CTDflavone results in increased expression of SOCS3 mRNA

flavone results in increased expression of SOCS3 protein

PMID:23782265
increases expressionISOCRRD:7308346480464CTDflavone results in increased expression of SOCS3 mRNA

PMID:23782265
multiple interactionsISOCRRD:7308336480464CTDdorsomorphin inhibits the reaction [flavone results in increased expression of SOCS3 protein]

PMID:23782265
multiple interactionsISOCRRD:7308346480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [flavone results in increased expression of SOCS3 protein]

AZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]

AZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 protein]

PMID:23782265
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.