GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621121
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cdk6
Name: cyclin-dependent kinase 6
Acc ID: CHEBI:69808
Term: 14-Deoxy-11,12-didehydroandrographolide
Definition: A diterpene lactone that has formula C20H28O4.
Chemical ID: MESH:C495626
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:7354016480464CTD14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK6 protein]

dorsomorphin inhibits the reaction [14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of CDK6 protein]]

PMID:30248417
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.